The Human Brain : From Neurone to Nervous System

AXOPLASMIC TRANSPORT


  1. Essential materials are packaged within vesicles that travel along the cytoskeleton in the interior of the axon at rates of up to 40 mm/day.

  2. Transport of materials from cell body to nerve terminals is called anterograde axonal transport, and from nerve terminals to the cell body is retrograde axonal transport.

  3. Retrograde transport informs the neuronal nucleus about the state of the nerve endings and the integrity of synaptic function. The neurotubular system also carries unwanted denatured or misfolded proteins back towards the perinuclear area (centrosome).

  4. It takes ~2.5 days for materials synthesised in neuronal cell bodies in the spinal cord to reach axon terminals in the human foot, around one metre distant, and a further ~2.5 days for a retrograde chemical message to do the return journey. This slow process informs the neuronal nucleus about the state of the nerve endings and the integrity of synaptic function.

  5. Key Words: anterograde and retrograde axoplasmic transport, cytoskeleton, neurotubules, kinesin, dynein, vesicles.












© Neurones.co.uk